Endocrine Abstracts

Introduction: Insulin sensitising agents are reported to have a diverse range of effects on bone with metformin exerting positive effects and thiazolidinenediones (TZDs) exerting negative effects. 5′AMP-activated protein kinase (AMPK) plays a critical role in cellular energy homeostasis. It is widely expressed in the body and can be activated by metformin.Aim: We investigated the role of AMPK pathway in mediating the effects of metformin on the ost...

Introduction: Heterozygote loss-of-function mutations in AIP (Aryl hydrocarbon receptor interacting protein) predispose to young-onset pituitary adenomas. Homozygote murine knockout model of AIP leads to lethality. While the majority of the 75 published AIP mutations result in truncated or missing proteins, missense mutations are more difficult to characterise and to establish their pathogenic role. We have identified the orthologue of AIP, CG1847, in Drosophila melanogaster. ...

Renalase is a recently discovered flavin adenine dinucleotide (FAD)-dependent oxidase, predominantly secreted into the circulation from the kidney and regulates catecholamine degradation and metabolism. Renalase gene is also present in heart muscle, skeletal muscle and liver cells in humans, and in mouse testicles. Four isoforms of renalase gene has been identified in humans (hRenalase1 to hRenalase4), however only hRenalase1 is detected in human blood suggesting that hRenalas...

Objectives: This study aims to determine which metabolic tissue is involved in the process of kisspeptin neurons regulate energy metabolism so that it may provide a novel therapy for metabolic related diseases such as obesity.Methods: Kiss1-CreGFP mice were used in this study. And we selectively activated kisspeptin neurons by using Designer-receptors-exclusively-activated-by-designer-drugs (DREADDs) technology. Mice were bilaterally injected with the Cr...

Aims: Maternal dyslipidemia during pregnancy is more serve in GDM women compared with non–GDM women. The occurrence of postpartum hyperglycemia is associated with increased lipid profiles. The purpose of this study was to evaluate the relationship between lipid changes and early postpartum abnormal glucose metabolism (AGM) of women with prior GDM history.Methods: 395 patients with a history of GDM who had a postpartum OGTT were included in this ret...

Introduction: Around 20–30% of patients with acromegaly have hyperprolactinemia, which is associated with infertility and gonadal/sexual dysfunction. Current therapy involves somatostatin analogues for GH/IGF1 excess and a dopamine agonist to decrease prolactin levels. The objectives of this analysis were to assess treatment with pasireotide LAR or octreotide LAR alone in patients with acromegaly and hyperprolactinemia.Methods: Patients with acromeg...

G protein-coupled receptors (GPCRs) are one of the largest families of the mammalian genome and represent the single most common therapeutic target. The glycoprotein hormones; LH and human chorionic gonadotrophin, act at a single GPCR the LH/hCGR, whose roles in reproductive function and pregnancy are well known. Endocytic trafficking of GPCRs represents a key mechanism in defining cellular responses in complex signaling pathways by controlling both the temporal and spatial pa...

For patients with Graves’ disease (GD), the primary goal of antithyroid drug therapy is to temporarily restore the patient to the euthyroid state and wait for a subsequent remission of the disease. This study sought to identify the predictive markers for the relapse of disease.To do this, we studied 262 GD patients with long enough follow-up after drug withdrawal to determine treatment outcome. The patients were divided into three groups by time of ...

Introduction: Abdominal obesity and insulin resistance are risk factors for erectile dysfunction (ED). ED is associated with hypoandrogenism, endothelial dysfunction, lower urinary tract symptoms (LUTS), and reduced quality of life (QoL). We aimed to compare effects of lifestyle modification-induced weight loss on insulin resistance, endothelial and sexual function, LUTS and QoL in obese non-diabetic men with and without ED.Methods: Seventy abdominally o...

Objective: Metformin was considered as a weight lowering agent in diabetes patients, while it remained unclear in simple obesity patients. We aimed to investigate if metformin is effective and safe in the therapy of normoglycemic obesity.Methods: We systematically searched MEDLINE (1950–2011), EMBase (1950–2011), and CCTR (4th Issue 2011), and collected and screened all randomized controlled trials compared metformin and placebo in obese partic...